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    <ns6:brs_depositor xml:lang="ja">中山　敬一</ns6:brs_depositor>
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    <ns1:strainDevelopment xml:lang="ja">九州大学生体防御医学研究所・中山敬一先生。E14 ES細胞を用いて作出。C57BL/6Jへ交配された（N7世代）。</ns1:strainDevelopment>
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    <ns1:strainDevelopment xml:lang="en">Developed by Keiichi Nakayama, Medical Institute of Bioregulation, Kyushu University.  E14 ES cells were used.  The mutant mice were crossed to C57BL/6J (N7 generations).</ns1:strainDevelopment>
    <ns4:application>Fluorescent Proteins/lacZ System</ns4:application>
    <ns1:donorDNA>E. coli Neomycin resistance gene, mouse phosphoglycerate kinase promoter, SV40 polyA signal, ECMV internal ribosomal entry site (ires), E. coli lacZ, phage P1 loxP</ns1:donorDNA>
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    <ns1:expectedDelivery xml:lang="ja">D（6か月以上）</ns1:expectedDelivery>
    <dc:description xml:lang="en">Fbxl21 gene knockout mice.  Exons 4 and 5 were replaced with an IRES-lacZ/neo cassette.</dc:description>
    <ns1:colonyMaintenance xml:lang="ja">Homozygote x Homozygote [or Crossing to C57BL/6JJcl]</ns1:colonyMaintenance>
    <ns1:colonyMaintenance xml:lang="en">Homozygote x Homozygote [or Crossing to C57BL/6JJcl]</ns1:colonyMaintenance>
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    <ns4:termsAndConditions xml:lang="ja">条件を付加する。利用者は提供承諾書を用いて、事前に寄託者の承諾を得る。&lt;br&gt;共同研究。</ns4:termsAndConditions>
    <ns1:expectedDelivery xml:lang="en">D (more than 6 months)</ns1:expectedDelivery>
    <ns4:termsAndConditions xml:lang="en">Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.</ns4:termsAndConditions>
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    <ns1:ESCellLine>E14 [129P2/OlaHsd]</ns1:ESCellLine>
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    <ns4:application>Metabolism Research</ns4:application>
    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Approval form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;&lt;A HREF="https://www.bioreg.kyushu-u.ac.jp/saibou/index_en.html" target="_blank"&gt;Lab HP&lt;/A&gt;</ns4:addinfo>
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    <rdfs:seeAlso rdf:resource="http://www2.brc.riken.jp/lab/animal/detail.php?brc_no=RBRC06388"/>
    <dcterms:references rdf:resource="http://identifiers.org/pubmed/23452856"/>
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    <ns4:application>Cre/loxP system</ns4:application>
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    <ns6:brs_depositor xml:lang="en">Keiichi NAKAYAMA</ns6:brs_depositor>
    <dc:description xml:lang="ja">Fbxl21遺伝子のノックアウトマウス。エクソン4と5をIRES-lacZ/neoカセットで置換。SCF&lt;Fbxl21&gt;のF-boxタンパク質サブユニットである。Fbxl21タンパク質はFbxl3タンパク質と84％のアミノ酸相同性を有しており、Fbxl3と同様にCRYタンパク質のユビキチン化に関わるが、Fbxl3と異なりCRYを細胞質において安定化させる働きがある。ホモマウスはFbxl3欠損マウスと異なり恒暗条件においても野生型とほぼ変わらない概日リズムを有するが、Fbxl3とFbxl21をともに欠損するマウスでは徐々に行動リズムが不安定化し、最終的にはリズムが消失する。</dc:description>
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    <skos:altLabel xml:lang="ja">Fbxl21 KO, B6-bxl21 KO</skos:altLabel>
    <skos:altLabel xml:lang="en">Fbxl21 KO, B6-bxl21 KO</skos:altLabel>
    <rdfs:label>B6;129P2-Fbxl21&lt;tm1Kei&gt;</rdfs:label>
    <rdfs:label xml:lang="en">B6;129P2-Fbxl21&lt;tm1Kei&gt;</rdfs:label>
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